The Egawa lab is interested in gene regulation of lymphocytes in the context of infection and cancer. Ongoing work in the lab seeks to understand the cellular dynamics of CD4 and CD8 T cell responses to chronic infection, hierarchical interactions between transcription factors underpinning differentiation of stem-like and effector T cell populations, and transcriptional regulation of malignant B cell transformation.

We are committed to creating a workplace where everyone feels safe and respected, regardless of their race, ethnicity, gender, sexual orientation, gender identity, religion, age, disability, or any other personal characteristic.

Congratulations to Yu Xia, a recent graduate of the lab, on receiving this year’s Spencer T. and Ann W. Olin Medical Fellowship award!

The Lab Team ➢

Meet the immunologists comprising the Egawa lab!

Our Research ➢

  • BCL6-dependent TCF-1+ progenitor cells maintain effector and helper CD4+ T cell responses to persistent antigen, Immunity, 2022
  • Unexpected suppression of tumorigenesis by c-MYC via TFAP4-dependent restriction of stemness in B lymphocytes, Blood, 2021
  • Identification of a T-bethi Quiescent Exhausted CD8 T Cell Subpopulation That Can Differentiate into TIM3+CX3CR1+ Effectors and Memory-like Cells, Journal of Immunology, 2021
  • The Transcription Factor AP4 Mediates Resolution of Chronic Viral Infection through Amplification of Germinal Center B Cell Responses, Immunity, 2016

Learn more about our previous and ongoing work!

Last updated 11/19/24