The Egawa lab is interested in gene regulation of lymphocytes in the context of infection and cancer. Ongoing work in the lab seeks to understand the cellular dynamics of CD4 and CD8 T cell responses to chronic infection, hierarchical interactions between transcription factors underpinning differentiation of stem-like and effector T cell populations, and transcriptional regulation of malignant B cell transformation.
The Egawa lab is currently looking for talented postdocs and graduate students to join our team. Please contact egawat@wustl.edu for more information!
We are committed to creating a workplace where everyone feels safe and respected, regardless of their race, ethnicity, gender, sexual orientation, gender identity, religion, age, disability, or any other personal characteristic.
Congratulations to Yu Xia, a recent graduate of the lab, on receiving this year’s Spencer T. and Ann W. Olin Medical Fellowship award!
Our Research ➢
BCL6-dependent TCF-1+ progenitor cells maintain effector and helper CD4+ T cell responses to persistent antigen, Immunity, 2022 
Unexpected suppression of tumorigenesis by c-MYC via TFAP4-dependent restriction of stemness in B lymphocytes, Blood, 2021 
Identification of a T-bethi Quiescent Exhausted CD8 T Cell Subpopulation That Can Differentiate into TIM3+CX3CR1+ Effectors and Memory-like Cells, Journal of Immunology, 2021 
The Transcription Factor AP4 Mediates Resolution of Chronic Viral Infection through Amplification of Germinal Center B Cell Responses, Immunity, 2016
Learn more about our previous and ongoing work!
Last updated 4/22/24